Roles of N 6 ‐methyladenosine (m 6 A) RNA modifications in urological cancers
نویسندگان
چکیده
منابع مشابه
Pseudouridine and N-methyladenosine modifications weaken PUF protein/RNA interactions
RNA modifications are ubiquitous in biology, with over 100 distinct modifications. While the vast majority were identified and characterized on abundant noncoding RNA such as tRNA and rRNA, the advent of sensitive sequencing-based approaches has led to the discovery of extensive and regulated modification of eukaryotic messenger RNAs as well. The two most abundant mRNA modifications—pseudouridi...
متن کاملN 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein
N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic messenger RNA (mRNA), and affects almost every stage of the mRNA life cycle. The YTH-domain proteins can specifically recognize m6A modification to control mRNA maturation, translation and decay. m6A can also alter RNA structures to affect RNA-protein interactions in cells. Here, we show that m6A increases the acc...
متن کاملPseudouridine and N6-methyladenosine modifications weaken PUF protein/RNA interactions.
RNA modifications are ubiquitous in biology, with over 100 distinct modifications. While the vast majority were identified and characterized on abundant noncoding RNA such as tRNA and rRNA, the advent of sensitive sequencing-based approaches has led to the discovery of extensive and regulated modification of eukaryotic messenger RNAs as well. The two most abundant mRNA modifications-pseudouridi...
متن کاملBenchmark data for identifying N(6)-methyladenosine sites in the Saccharomyces cerevisiae genome.
This data article contains the benchmark dataset for training and testing iRNA-Methyl, a web-server predictor for identifying N(6)-methyladenosine sites in RNA (Chen et al., 2015 [15]). It can also be used to develop other predictors for identifying N(6)-methyladenosine sites in the Saccharomyces cerevisiae genome.
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Personalized medicine (PM) refers to a set of medical, diagnostic, and therapeutic activities and approaches based on the specific characteristics of each patient chr ('39')s genome. In fact, individual-centered medical approaches are based on personalization, meaning that each person chr ('39')s gene sequence and polymorphisms (SNPs) are different and explain the different courses of urologica...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2020
ISSN: 1582-1838,1582-4934
DOI: 10.1111/jcmm.15750